Radioactive iodine therapy for thyroid cancer

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This therapy can destroy tiny amounts of normal thyroid tissue or cancer cells, if any, left behind after surgery. It is usually given after surgery for papillary or follicular thyroid cancer. You may have to wait several weeks to recover after surgery.

Not all patients need radioactive iodine therapy. You will be referred to a specialist centre for this treatment if you need it 

Preparing for radioactive iodine therapy 

High TSH level

You will need a high level of thyroid-stimulating hormone (TSH) in your bloodstream for the treatment to be a success. This hormone activates thyroid cells and encourages them to absorb the radioactive iodine. The level of TSH can be raised by: 

  • Taking recombinant TSH: Recombinant human TSH (rhTSH) boosts the level of TSH in your body to make sure the radioactive iodine therapy works. It is given as two injections into your buttocks over 2 days before the iodine capsule is taken. 
  • Stopping hormone therapy: Your doctor might ask you to stop taking your hormone replacement tablets about 4‒6 weeks before the therapy. This is because these hormones stop TSH from being made. Stopping the hormone therapy can make you feel more tired, but this will ease once the medication is resumed. Usually only a small number of patients are asked to stop taking their hormone therapy.

Low-iodine diet

If there’s less iodine in your body it will be more willing to take up the radioactive iodine, so you may be told to limit the iodine in your diet for 2 weeks before your treatment. Your nurse will tell you what foods to avoid.

Pregnancy and breastfeeding

Use a reliable method of contraception before you start treatment – it’s important not to become pregnant or father a child during treatment and for a few months afterwards. Ask your doctor about this. Tell your doctor if there’s a chance you might be pregnant. Radioiodine treatment can harm the baby and so isn’t suitable for pregnant women. 

If you are breastfeeding, you must stop a couple of days before your treatment. In fact, it is best if your child is weaned before treatment, or postpone it until your baby is weaned. It is not safe to start breastfeeding again after your treatment, but future pregnancies and breastfeeding will not be affected.

Getting radioactive iodine therapy

Usually you will be given a small pill. The radioiodine goes into your bloodstream and travels to thyroid cells in your body. The thyroid cells absorb the radioiodine and it kills them.

Other cells in your body will not be harmed as they do not absorb the radioiodine. The treatment can be repeated if thyroid cells are still present.

After radioactive iodine therapy

The therapy makes you radioactive for a few days. There is a chance that the hospital staff and your relatives and friends might be exposed to the radiation. No visitors are allowed for the first 24 hours. After that they are only allowed in your room for a short time each day, one at a time and they must stay at a distance from you. Lead screens may be placed on either side of your bed or in the doorway to block any radiation. Children under 14 and pregnant women will not be allowed to visit you for up to 5 days. 

It is best to drink lots of fluids as this will get rid of the radioactivity quicker. The medical physicist will measure your radiation levels every day to make sure they have dropped to a safe level. Usually after 3 days you will be allowed home. Usually a whole body scan is done before you go home or the following week. 

Feeling isolated: You might feel lonely, afraid and even depressed having to stay in isolation. Tell your nurses how you’re feeling. Usually there is a telephone in the room or you can use a mobile phone to talk to your family and friends.

Hints and tips: Safety after radioactive iodine therapy

For 2 weeks after you go home it’s best to:

  • Avoid close contact with people 
  • Keep a distance of at least 3 feet (1 metre) from everyone. Double this amount for pregnant women and young children
  • Sleep in a separate bed 
  • If you have a small baby, get your partner, relative or friend to care for them 
  • Do not breastfeed your baby 
  • Avoid long journeys on trains, taxis, buses or aeroplanes 
  • Avoid social events or entertainment venues (cinema, theatre, stadiums, festivals, etc.) for at least a week 
  • Do not return to work or school for at least a week, or longer if you work with children 
  • Flush the toilet 2/3 times after using it 
  • Bathe or shower frequently 
  • Rinse your toothbrush thoroughly 
  • Do not share cutlery, crockery, towels and bed linen unless washed once

Do talk to your medical physicist before leaving hospital if you are planning to travel. You will be given a letter for airport authorities in case the security scanners pick up any radioactivity.

Side-effects of radioactive iodine therapy

  • Tiredness: You might feel tired, especially if your thyroid hormone therapy has been stopped. Read more about coping with fatigue.
  • Swelling: The radioiodine might cause a slight swelling under your jaw or salivary glands. This does not last long and can be eased by sucking on sharp-tasting sweets like lemon drops.
  • Fertility effects: If you are a woman, your periods might stop or become irregular for several months after radioiodine therapy, but this is only temporary. Many people, especially younger patients, go on to have normal pregnancies and births.

    For men, radioiodine may affect their sperm count and levels of testosterone briefly. But you will be able to father a child. It is best to wait at least 6 months after treatment before you go ahead.

  • Other side-effects: Rare side-effects include pain, feeling breathless, a dry mouth, or altered taste. 

Let your doctor or nurse know if you are worried about any side-effects after radioactive iodine therapy.

For more information

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