Fertility issues for women

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Some cancer treatments can damage the eggs in your ovaries or affect the hormones that make your body release eggs and get ready for pregnancy. For example:

  • Radiotherapy to the pelvic area can damage some or all of your eggs. 
  • Hormone therapy and some other cancer drugs can lead to a temporary or permanent menopause or cause birth defects.
  • Chemotherapy drugs can damage a woman’s eggs.  
  • Some types of surgery can affect your fertility. For example if you have your womb removed (hysterectomy) or ovaries removed. 

If your hormone levels or eggs are affected by treatment, you may have difficulty getting pregnant or it may not be possible for you to get pregnant. 

Short-term infertility

Your periods may become irregular or stop during treatment with chemotherapy or other cancer treatments. You may not get a period for a few months after treatment. You may also get hot flushes, a dry vagina or other symptoms of the menopause. But after a few months your periods may return to normal. This happens to about a third of women. The younger you are, the more likely your periods will return to normal and you can get pregnant naturally.

Ovarian transposition

Radiotherapy to your pelvic area is likely to affect your ovaries. You might be able to have a small surgery to move your ovaries away from the treatment area. This is called ovarian transposition. 

Menopause

Unfortunately, the nearer you are to menopause, the more likely your periods will stop permanently. This means that your chances of having a child in the future are significantly reduced. Usually it is not possible to stop this happening. 

Hormone replacement therapy (HRT) drugs can reduce menopausal symptoms, like hot flushes and a dry vagina. The treatment can be given as a tablet or through an implant under your skin, by creams or by a slow-release patch worn on your arm or leg. Read more about managing menopausal symptoms

Avoiding pregnancy

You may not know if you are fertile or not, as your periods may stop during treatment. But it may still be possible for you to become pregnant during treatment. Also, side-effects of like vomiting and diarrhoea can make the contraceptive pill work less well. For this reason, you must use a reliable method of contraception throughout your treatment and for some time afterwards. Some cancer drugs can harm your baby, especially in the first 3 months of pregnancy. There can also be a risk of miscarriage.

Freezing eggs 

If there is a risk that your treatment will cause permanent infertility, you may have the option of freezing your eggs (oocytes) before treatment begins. Not all women are suitable for egg freezing. It will depend on the type and location of your cancer, your age and medical history. 

If you still want to have children, discuss this as early as possible with your cancer specialist before treatment.

There may not be time to collect and freeze eggs if your consultant advises you that treatment needs to start as soon as possible. Your health will take priority over egg freezing. 

If egg freezing might be an option for you, your consultant can refer you to Rotunda IVF at the Rotunda Hospital in Dublin or another fertility clinic. 

You will be offered counselling, and you can ask questions and discuss any concerns you may have.

Who’s suitable? You must be over 18, be able to give informed consent and be referred by your cancer specialist (oncologist). 

How are eggs frozen? 
Your ovaries will need to be stimulated to produce several eggs for storage. There are different ways of doing this and your doctor will decide which option is best for you and when you can start. This will sometimes depend on your menstrual cycle. 

The aim will be to collect eggs within three weeks. Generally, you will have daily injections to stimulate egg production and be monitored for about 12 days, followed by a procedure to remove the eggs. 

It may happen that no eggs develop or that they are not suitable for freezing. But this will be explained to you.

If the eggs are successfully collected, they are stored for between 5 and 10 years or until you are 45. It may be possible to extend this period in certain circumstances. Contact Rotunda IVF for more details. 

How much does egg freezing cost?
Collecting and storing eggs at Rotunda IVF is currently free for all cancer patients living in Ireland. Before your appointment, check that this is still the case. Private fertility clinics are also available.

Trying to conceive? 
You should talk to your oncologist if you want to use your frozen eggs. They can tell you if it is safe for you to try to get pregnant. You will then need to contact Rotunda IVF to discuss your options. 

The clinic encourages women to use their frozen eggs by the age of 40. After that age, there is a high chance of complications and you are less likely to have a successful pregnancy.

When ready, your frozen eggs can be thawed and fertilised in the laboratory. This is done using a form of in-vitro fertilisation (IVF) called intracytoplasmic sperm injection (ICSI). The fertilised eggs will then be put into your womb in the hope of a pregnancy. Before this happens, you will be given tablets to build up the lining of your womb.

Where can I be treated? 
You can decide to have this treatment at Rotunda IVF. If you decide to be treated elsewhere, it is possible for the frozen eggs to be transferred to a clinic of your choice. However, your clinic must agree to it beforehand and the transfer is done at your own risk.

Where can I get more information? If you would like more information about egg freezing, talk to your doctor or nurse. You can also call the Support Line on 1800 200 700. Your GP can give you advice as well.

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