Skin and nail changes

Some cancer treatments can cause skin or nail problems. Most skin changes get better after you stop treatment. 

Skin changes

You may notice:

  • Dry, itchy, flaky or peeling skin
  • Sore or sensitive skin
  • A rash, which can range from mild to severe, anywhere on your body
  • Small bumps, pimples or an acne-like rash
  • Darkened skin in some areas
  • Your skin may become more sensitive to sunlight, which means you are more likely to sunburn
Hand-foot syndrome

Hand-foot syndrome (also called palmar-plantar erythrodysesthesia) can happen with some cancer treatments. This can cause redness, swelling, tenderness or pain, or dry, peeling or blistering skin on the palms of your hands and/or the soles of your feet. It can sometimes look like a sunburn.

Managing skin changes

Dry skin

Keeping your skin well moisturised can help with dryness, flaking and discomfort. Your healthcare team may recommend moisturising creams or ointments.

They may also suggest changes to your usual skincare routine. Follow the advice of your medical team, as some products may not be suitable during cancer treatment. 

If you are having radiotherapy, check with your radiotherapy team before using any creams or lotions on the treatment area.

We also have some skincare tips below.

Rash or itching

Tell your nurse or doctor if you develop a rash or itchy skin. There are creams and medicines that can help.

Sometimes a rash or itch could be a sign that you are reacting to a drug, so always let your medical team know straight away if you notice any skin changes.

Increased sensitivity to sunlight

Some cancer treatments can make your skin more sensitive to sunlight. To protect your skin:

  • Avoid direct sun exposure, especially when UV rays are at their strongest (peak daylight hours). In Ireland, this is generally from 11am to 3pm, April to September. 
  • Stay in the shade whenever possible. 
  • Wear protective clothing, a wide-brimmed hat and sunglasses that give 100% UV protection or that have a CE mark.
  • Avoid exposing your skin to the sun if you have had radiotherapy.
  • Wear sunscreen with a sun protection factor (SPF) of at least 30 (SPF 30+) or SPF 50+ for children. Reapply sunscreen regularly, especially after swimming or sweating. If you are having radiotherapy, do not apply sunscreen or other creams to the treatment area without checking with your radiotherapy team first. 

Skincare tips

  • Moisturise your skin regularly.
  • Avoid perfumed products and products containing alcohol.
  • Protect your skin in cold weather by covering up well.
  • Protect your skin from the sun using protective clothing and broad-spectrum sunblock (SPF 30 or more for adults and SPF 50+ for children). 
  • Use emollient creams to help soothe dry or itchy skin.
  • Avoid scratching or rubbing irritated skin.
  • Pat your skin dry gently with a soft towel after bathing or showering.
  • Avoid wet shaving in areas affected by treatment. Use an electric razor instead.
  • Wear loose, comfortable clothing made from natural fibres such as cotton.

Nail changes

Some cancer treatments can affect the health and appearance of your nails. Nails may become:

  • Dry, brittle or weak
  • Discoloured
  • Ridged or uneven
  • Painful or sensitive

Occasionally, a nail may become loose or fall off. 

Tell your nurse or doctor about any nail changes you notice during treatment. Your nails should gradually return to normal after treatment finishes.

Contact your healthcare team straight away if you notice:

  • Redness around the nail
  • Swelling
  • Pain
  • Pus or discharge
  • Any other signs of infection

Nail care tips

  • Keep your nails short and clean. 
  • File nails gently in one direction rather than back and forth. This avoids splitting your nails.
  • Use a moisturising or nail-strengthening cream to help with dryness.
  • If using nail varnish, choose a water-based product. When removing nail varnish use an acetone-free nail polish remover to prevent drying your nails.
  • Avoid nail varnish if your nails are split, damaged or painful.
  • Avoid false nails, gel nails and acrylic nails during treatment.
  • Do not cut your cuticles. Instead, use cuticle cream to keep them moisturised.
  • Wear gloves when doing housework or washing dishes. Excessive exposure to water can lead to fungal infections of the nail bed.
  • Wear comfortable footwear that does not put pressure on your toenails.
  • Report any nail or skin changes to your healthcare team.

Feeling self-confident

Changes to your skin, nails and appearance can affect your confidence during cancer treatment.

Look Good Feel Better offers free workshops and practical advice to help people manage the visible side-effects of cancer treatment and feel more confident.


We're here to help

Our range of free services are here for you

Patient Education
Our free patient education group sessions and video resources provide information to guide you through and beyond cancer treatment.
Peer Support
Peer Support is a free and confidential phone service connecting people with similar cancer experiences. Our volunteers are trained to provide emotional and practical cancer support.
Eating well and exercise support
Eating well and exercise can help you feel better before, during and after cancer treatment. We can provide information and support on maintaining a healthy diet and being physically active.

Talk to a Cancer Nurse

Support Line

Support Line

Support Line
Our Cancer Nurses offer confidential advice, support and information for anyone affected by cancer. Call or email supportline@irishcancer.ie. Video calls available. Mon-Fri: 9am-5pm
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Our Daffodil Centres

Our Daffodil Centres
Our Daffodil Centres in 13 hospitals nationwide are staffed by Cancer Nurses and trained volunteers who provide face-to-face advice, support and information for anyone affected by cancer.