Stem cell transplants using another person’s stem cells (allogeneic transplants)

• Blood tests: Blood tests can show the numbers of different types of blood cells. This is called a full blood count. Doctors will also check your blood group, clotting and iron levels and how well your kidneys, liver and bones work. They will also check for the presence of viruses, for example, HIV, hepatitis A, B, C and syphilis.
• 24-hour urine collection: This test checks how well your kidneys are working. You will be given a large plastic bottle to bring home with you to collect your urine. You will be asked to collect all the urine you pass in a 24-hour period. You do this at home. It is important to collect all the urine you pass in the bottle or the test will have to be repeated. To measure the results, you will need a blood test taken when you return the urine collection to the hospital.
• Dental check-up: Before you have the high-dose chemotherapy, a dentist needs to check your teeth. This is because decaying teeth can cause a serious infection during treatment. You can visit your own dentist for this check-up. Your doctors will need a letter from your dentist saying that you are dentally fit for the transplant
• Testing for bacteria: Certain bacteria which are not usually harmful may cause infection after high-dose chemotherapy. Tests will help your doctor choose the correct antibiotics if you do become unwell.
• Lung function tests
• Chest X-ray
• Heart tests (ECG and echocardiogram (ECHO)

You may have other tests, depending on your condition and medical history. For example, bone marrow biopsy and lumbar puncture. Read more about cancer tests.

Before your high-dose chemotherapy, you will need a special line (tube) placed in a large vein. Any treatment or medication that needs to go into your veins can be delivered through the line, meaning there is no need for needles in your arms every time.  It can stay in place during and for a time after your treatment. Read more about central lines.

You may have chemotherapy before your stem cell collection, to reduce the number of cancer cells.

You can expect to be in hospital for about 6 weeks. If you live more than an hour from the transplant centre, you will need to stay in the Dublin area for about another 6 weeks. Before treatment you may want to:

• Organise your finances, including any social welfare benefits you may be entitled to
• Talk to your employer about sick leave
• Organise childcare
• Organise a family member or carer to stay with you for 6 weeks after you leave hospital
• Ask a close friend or family member to provide updates to everyone else

The medical social worker in your hospital will be able to help and advise you about some of these issues.

High dose treatment can affect your ability to have children in the future. Talk to your medical team before treatment if this is important to you. It may be possible to freeze your eggs or sperm.

Doctors use your tissue type to match you with a donor. Your tissue type is the combination of proteins called human leukocyte antigen (HLA) markers on the surface of your cells. You will have a blood test to find your tissue type. There are different types of donors:

• Sibling: a brother or sister. If you have a brother or sister are most likely to have a good match for your tissue type, so they will be tested first.
• Alternative family donor: a parent, cousin or child
• MUD: a volunteer Matched Unrelated Donor

All donors will need tests such as blood tests and a chest X-ray to make sure that they are fit and healthy. 

Having the best possible match means less risk of:

• Your body rejecting the new stem cells
• The new immune cells reacting against your other body cells.

It is best that only your close family and friends visit you during your stay. This is to reduce the chance of you and other patients picking up an infection. The best advice is that no more than two people visit you at any one time.
 

Being in isolation after the transplant can be stressful. Naturally you might find it difficult being on your own without other patients around you. Your nurses can help you overcome these difficulties and will make your stay as non-traumatic as possible. They can arrange for you to talk to a clinical psychologist to explore your feelings and try to help you cope.
 

Keeping active helps to keep your muscles working and is important for your lungs. Get up and walk around the room at least a few times a day. Even getting up to go to the toilet and to wash yourself helps with your recovery. You will be allowed to exercise and the occupational therapist or physiotherapist may plan an activity programme for you. You may be allowed out of the room for short periods when your blood count has started to rise.
 

You need to contact the hospital immediately if you develop any of the symptoms listed below or if you if feel unwell in any way. It is very common for patients to be re-admitted to hospital in the weeks or months following discharge. Try not to feel worried or disappointed if this happens to you.

Central line

• Shivering episode after flushing your line
• Swelling, tenderness or pus around your line

Bowels

• Persistent diarrhoea or constipation
• Change in the colour or consistency of your stools (poo)
• Cramps

Urine

• Change in colour
• Pain or burning sensation
• Red urine, clots or difficulty passing urine

Skin

• Any kind of a rash
• Itching

Temperature/shivering

• Temperature over 38ºC, with or without shivering
• Shivering with or without a temperature

Pain

• A persistent headache that does not respond to paracetamol
• Stomach ache
• Gut cramps
• Joint pain
• Mouth ulcers or a sore throat

Nausea or vomiting

• Let the hospital know if this is new or is preventing you from drinking or taking your medication.

Medicine

• Let the hospital know if you’re unable to take your medication for any reason.

Bleeding

• Any signs of bleeding or bruising. For example bleeding gums, or blood in the urine or stools (poo)
• Persistent nosebleed

Cough or breathlessness

• A new or persistent or worsening cough
• Shortness of breath or increasing shortness of breath

For the first few weeks after your transplant you need regular check-ups, often daily at first. This is called follow-up. You might need regular blood or platelet transfusions. Once your blood counts are stable and your strength is improving, you will have fewer appointments. Your doctor will decide how often you need to be seen.

It is likely that you will need follow-up appointments for a long time after your transplant. This will depend very much on your original disease but you may need blood tests, bone marrow tests or scans.

Your central line can usually stay in until your blood counts are high enough to allow it to be removed. If the line needs to stay in place, you or a family member will be shown how to care for it at home. It will also need to be cared for weekly with a flush and dressing change on the day unit.
 

You will have medications to take at home. Some of the common ones are:

• Anti-sickness medication, but you may not experience nausea or vomiting at all
• Antacid – to treat heartburn
• Antibiotics to protect against a particular strain of pneumonia
• Anti-viral drugs to protect against the cold sore and shingles virus

Continue to take any medications you are given until your doctor decides to stop them.

For the first few weeks after the transplant your energy levels will be very low. Fatigue can be a frequent and unpleasant side-effect. You will probably find you have no energy and do not feel like doing anything at first. Just getting up, washed and dressed can be a challenge in the first few weeks. Don’t expect too much from yourself – take one day at a time. This tiredness can last for a few months but sometimes can take longer to overcome. Read more about coping with fatigue.
 

Even if your blood counts are back to normal, your immune system takes a little longer to recover. Continue to be careful. For example:

• Continue to shower every day and be strict about your personal hygiene.
• Continue your mouthwashes until your next visit to the day ward.
• Avoid people with infections.
• Avoid areas that are overcrowded.
• Avoid close contact with pets, especially birds, in the first few weeks.
• Avoid swimming if you go home with your central line in place.
• Keep your fridge clean.

You may find that you don’t have much appetite or your taste and sense of smell has changed. Foods that you loved before might now begin to taste and smell different. Try not to worry as your appetite and taste will gradually improve. It’s important to eat as well as you can, so ask to talk to the hospital dietitian if you’re experiencing problems or losing weight. We also have advice on eating difficulties, including tips to help if your appetite is poor. 

Aim to drink 2 to 3 litres of fluid a day to speed up your recovery. Your mouth may continue to feel dry after your transplant so drinking plenty of fluids will also help with this. Often it is best to avoid alcohol for a time after your transplant. Talk to your doctor for more advice about alcohol.

It is likely that after your transplant your sex life will be affected in some way. Tiredness, anxiety and lack of interest can often be the reason. It is likely that once your energy levels return to normal so too will your sex drive (libido). If your platelets or white cells are low, ask your nurse for advice about having sex. Your nurse can help and support with issues affecting your sex life or close relationships.

Even though you are likely to be infertile after the high-dose chemotherapy, there is no guarantee that it will happen. Research suggests that a small number of patients recover fertility after a transplant. It is important to use reliable contraception such as a condom after chemotherapy to avoid pregnancy. This is because the drugs might harm a developing baby. Your doctor or nurse will advise you on this.