Symptoms and diagnosis of chronic lymphocytic leukaemia (CLL)


The most common symptoms of CLL include:

  • Tiredness
  • Anaemia (fewer red blood cells)
  • Shortness of breath
  • Recurrent infections
  • Bleeding and unexplained bruising
  • Fever
  • Night sweats
  • Aching bones and joints
  • Weight loss
  • Swollen lymph glands in your neck, armpits and groin
  • Enlarged liver or spleen
  • Discomfort in your abdomen

Even though these symptoms can be caused by conditions other than leukaemia, do have them checked by your family doctor (GP).


Testing for cancer when you have no symptoms is called screening. There is no national leukaemia screening programme in Ireland or anywhere else in the world. If you are worried about leukaemia, contact the National Cancer Helpline on 1800 200 700 or speak to your GP.


Visit your family doctor (GP) first if you are worried about any symptoms. He or she will examine you and arrange blood tests if needed. If your blood test is abnormal, you will be referred to a specialist called a haematologist, who treats abnormal changes to blood and bone marrow. At the hospital, some of the following tests may be done to diagnose CLL:

  • Physical exam
  • Blood tests, such as a full blood count
  • Bone marrow biopsy

A bone marrow biopsy involves taking a small sample of marrow from the inside of your hip or breastbone and examining it under a microscope. Special tests can also be done on blood or bone marrow samples. For example, the number and shape of chromosomes in your blood cells can be examined and compared to normal cells. Immunophenotyping can check what kind of proteins or markers are on the surface of the leukaemia cells.

Other tests

  • Blood tests
  • Lymph gland biopsy
  • CT scan

The above scans can help to stage the cancer. This means finding out the size of the cancer and if it has spread anywhere else. This can help your doctor to decide the right treatment for you.

Learn more about the above tests

Call our National Cancer Helpline

Freephone 1800 200 700 to talk to a specialist cancer nurse
It's open Monday-Thursday from 9am to 7pm and Friday from 9am to 5pm