2013 Research Publications

Irish Cancer Society-funded research produced the following 38 scientific publications in 2013:

(Note: If you have published work funded by an Irish Cancer Society grant which is not listed below, please contact us at research@irishcancer.ie)

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All Cancers (15 publications)

Article Title Redox Regulated Growth Factor Survival Signalling  
Authors Woolley JF, Corcoran A, Groeger G, Landry WD, Cotter TG
Year 2013
Journal Antioxidants & Redox Signaling
Publication Type Review

 
Article Title Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?
Authors Griffin MD, Ryan AE, Alagesan S, Lohan P, Treacy O, Ritter T.
Year 2013
Journal Immunology and Cell Biology
Publication Type Review

 
Article Title Chondrogenic differentiation increases anti-donor immune response to allogeneic mesenchymal stem cell (MSC) transplantation 
Authors Ryan AE, Lohan P, O'Flynn L, Treacy O, Chen X, Coleman C, Shaw G, Murphy M, Barry F, Griffin MD, Ritter T
Year 2013
Journal Molecular Therapy
Publication Type Original Article 

 
Article Title Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase
Authors Lall P, Horgan CP, Oda S, Franklin E, Sultana A, Hanscom SR, McCaffrey MW, Khan AR
Year 2013
Journal Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Publication Type Original Article

Article Title GRAB is a binding partner for the Rab11a and Rab11b GTPases
Authors Horgan CP, Hanscom SR, McCaffrey MW
Year 2013
Journal Biochemical and Biophysical Research Communications
Publication Type Original Article

Article Title Identification and characterization of multiple novel Rab-myosin Va interactions
Authors Lindsay AJ, Jollivet F, Horgan CP, Khan AR, Raposo G, McCaffrey MW, Goud B
Year 2013
Journal Molecular Biology of the Cell
Publication Type Original Article

Article Title Mining methylome databases
Authors O'Rourke CJ, Murphy TM, Hollywood D, Perry AS.
Year 2013
Journal Trends in Genetics
Publication Type Review

Article Title Use of optical imaging to progress novel therapeutics to the clinic
Authors Byrne WL, DeLille A, Kuo C, de Jong JS, van Dam GM, Francis KP, Tangney M. 
Year 2013
Journal Journal of Controlled Release
Publication Type Original Article

Article Title Bacterial-directed enzyme prodrug therapy
Authors Lehouritis P, Springer C, Tangney M.
Year 2013
Journal Journal of Controlled Release
Publication Type Review

Article Title Plasmid Transgene Expression In Vivo; Promoter and Tissue Variables
Authors Morrissey D, Collins SA, Rajendran S, Casey G, O'Sullivan GC, Tangney M
Year 2013
Journal Gene Therapy - Tools and Potential Applications
Publication Type Book Chapter

Article Title  Current Concepts in ER Stress-Induced Apoptosis
Authors Logue SE, Gorman AM, Cleary P,Keogh N, Samali A
Year 2013
Journal Carcinogenesis & Mutagenesis
Publication Type Review

Article Title New directions in ER stress-induced cell death 
Authors Logue SE, Cleary P, Saveljeva S, Samali A
Year 2013
Journal Apoptosis
Publication Type Review

Article Title Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1
Authors Abreu CM, Kumar R, Hamilton D, Dawdy AW, Creavin K, Eivers S, Finn K, Balsbaugh JL, O'Connor R, Kiely PA, Shabanowitz J, Hunt DF, Grenon M, Lowndes NF.
Year 2013
Journal PLoS Genetics
Publication Type Original Article 

Article Title Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways
Authors van Dijk M, Halpin-McCormick A, Sessler T, Samali A, Szegezdi E
Year 2013
Journal Cell Death and Disease
Publication Type Original Article 

Article Title Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling
Authors Sessler T, Healy S, Samali A, Szegezdi E
Year 2013
Journal Pharmacology and Therapeutics
Publication Type Review

Breast Cancer (2)

Article Title C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy
Authors Pertl MM, Hevey D, Boyle NT, Hughes MM, Collier S, O'Dwyer AM, Harkin A, Kennedy MJ, Connor TJ 
Year 2013
Journal Brain Behaviour and Immunology
Publication Type Original Article 

Article Title miR-379 regulates cyclin B1 expression and is decreased in breast cancer.
Authors Khan S, Brougham CL, Ryan J, Sahrudin A, O'Neill G, Wall D, Curran C, Newell J, Kerin MJ, Dwyer RM 
Year 2013
Journal PLoS One 
Publication Type Original Article 

Cervical Cancer (1)

Article Title Evaluation of the clinical performance
Authors White C, Keegan H, Pilkington L, Ruttle C, Kerr P, Sharp L, O'Toole S, Turner M, Prendiville W, D'Arcy T, Fitzpatrick M, Lenehan P, Flannelly G, O'Leary JJ, Martin CM
Year 2013
Journal Journal of Clinical Microbiology
Publication Type Original Article

Colorectal Cancer (4)

Article Title Targeting the EP1 receptor reduces fas ligand expression and increases the anti-tumor immune response in an in vivo model of colon cancer
Authors O'Callaghan G, Ryan A, Neary P, O'Mahony C, Shanahan F, Houston A
Year 2013
Journal International Journal of Cancer
Publication Type Original Article

Article Title The relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients
Authors Fitzgerald S, Sheehan KM, O'Grady A, Kenny D, O'Kennedy R, Kay EW, Kijanka GS
Year 2013
Journal Journal of Gastroenterology and Hepatology
Publication Type Original Article

Article Title A cohort study of metformin exposure and survival in patients with stage I-III colorectal cancer
Authors Spillane SC, Bennett K, Sharp L, Barron TI
Year 2013
Journal Cancer Epidemiology, Biomarkers & Prevention
Publication Type Original Article

Article Title Adenovirus-mediated transcriptional targeting of colorectal cancer and effects on treatment-resistant hypoxic cells
Authors Rajendran S, O'Sullivan GC, O'Hanlon D, Tangney M
Year 2013
Journal Clinical Colorectal Cancer
Publication Type Original Article

Gastrointestinal Cancer (1)

Article Title Could Signal Transducer and Activator of Transcription 3 be a Therapeutic Target in Obesity-Related Gastrointestinal Malignancy?
Authors O'Sullivan KE, Reynolds JV, O'Hanlon C, O'Sullivan JN, Lysaght J
Year 2013
Journal Journal of Gastrointestinal Cancer 
Publication Type Review

Leukaemia (2)

Article Title Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib
Authors Landry WD, Woolley JF, Cotter TG
Year 2013
Journal Leukemia Research 
Publication Type Original Article

Article Title Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox
Authors Vincenz L, Jäger R, O'Dwyer M, Samali A
Year 2013
Journal Molecular Cancer Therapeutics
Publication Type Original Article

Lung Cancer (3)

Article Title Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC
Authors Heavey S, O'Byrne KJ, Gately K
Year 2013
Journal Cancer Treatment Reviews
Publication Type Review

Article Title Targeting nuclear factor-kappa B to overcome resistance to chemotherapy
Authors P. Godwin, A. M. Baird, S. Heavey, M. P. Barr, K. J. O’Byrne and K. Gately
Year 2013
Journal Frontiers in Oncology
Publication Type Review

Article Title MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells
Authors Barkley LR, Santocanale C
Year 2013
Journal Oncogenesis
Publication Type Original Article

Multiple Myeloma (1)

Article Title Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma
Authors Vincenz L, Jäger R, O'Dwyer M, Samali A
Year 2013
Journal Molecular Cancer Therapeutics
Publication Type Original Article

Oesophageal Cancer (1)

Article Title MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation
Authors Allott EH, Lysaght J, Cathcart MC, Donohoe CL, Cummins R, McGarrigle SA, Kay E, Reynolds JV, Pidgeon GP
Year 2013
Journal Molecular Carcinogenesis
Publication Type Original Article

Ovarian Cancer (1)

Article Title BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation
Authors Stordal B, Timms K, Farrelly A, Gallagher D, Busschots S, Renaud M, Thery J, Williams D, Potter J, Tran T, Korpanty G, Cremona M, Carey M, Li J, Li Y, Aslan O, O'Leary JJ, Mills GB, Hennessy BT
Year 2013
Journal Molecular Oncology
Publication Type Original Article 

Prostate Cancer (6)

Article Title Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?
Authors Guo J, Evans JC, O'Driscoll CM
Year 2013
Journal Trends in Molecular Medicine
Publication Type Review

Article Title Gene expression analysis in prostate cancer: The importance of the endogenous control
Authors Vajda A, Marignol L, Barrett C, Madden SF, Lynch TH, Hollywood D, Perry AS
Year 2013
Journal Prostate
Publication Type Original Article 

Article Title Prostate cancer epigenomics
Authors Perry AS
Year 2013
Journal The Journal of Urology
Publication Type Editorial

Article Title Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer
Authors Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O\'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, Barrett C, Loftus B, Thornhill J, Hewitt SM, Lawler M, Kay E, Lynch T, Hollywood D
Year 2013
Journal International Journal of Cancer
Publication Type Original Article 

Article Title Aberrant PSA glycosylation--a sweet predictor of prostate cancer
Authors Gilgunn S, Conroy PJ, Saldova R, Rudd PM, O'Kennedy RJ
Year 2013
Journal Nature Reviews Urology
Publication Type Review

Article Title Evaluation of prediction models for the staging of prostate cancer
Authors Boyce S, Fan Y, Watson RW, Murphy TB
Year 2013
Journal BMC Medical Informatics and Decision Making
Publication Type Original Article 

Urological Cancers (1)

Article Title Manipulating the epigenome for the treatment of urological malignancies
Authors O'Rourke CJ, Knabben V, Bolton E, Moran D, Lynch T, Hollywood D, Perry AS.
Year 2013
Journal Pharmacology & Therapeutics
Publication Type Review