2012 Research Publications

Irish Cancer Society-funded research produced the following 47 scientific publications in 2012:

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All Cancers (13)
Brain Cancer (3)
Breast Cancer (3)
Colorectal Cancer (1)
Gastrointestinal Cancer (1)
Leukemia (3)
Lung Cancer (1)
Oesophageal Cancer (11)
Ovarian Cancer (3)
Prostate Cancer (8)


All Cancers (13 publications)

Article Title Methodological challenges in researching psychological distress and psychiatric morbidity among patients with advanced cancer: What does the literature (not) tell us?  
Authors Ryan, D (Ryan, Dermot); Gallagher, P (Gallagher, Pamela); Wright, S (Wright, Shelagh); Cassidy, E (Cassidy, Eugene) 
Year 2012
Journal PALLIATIVE MEDICINE
Publication Type Review

Article Title Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL  
Authors Szegezdi, E (Szegezdi, Eva); van der Sloot, AM (van der Sloot, Almer M.); Mahalingam, D (Mahalingam, Devalingam); O'Leary, L (O'Leary, Lynda); Cool, RH (Cool, Robbert H.); Munoz, IG (Munoz, Ines G.); Montoya, G (Montoya, Guillermo); Quax, WJ (Quax, Wim J.); de Jong, S (de Jong, Steven); Samali, A (Samali, Afshin); Serrano, L (Serrano, Luis) 
Year 2012
Journal MOLECULAR & CELLULAR PROTEOMICS
Publication Type Original Article 

Article Title Prospective Study of Falls and Risk Factors for Falls in Adults With Advanced Cancer  
Authors Stone, CA (Stone, Carol A.); Lawlor, PG (Lawlor, Peter G.); Savva, GM (Savva, George M.); Bennett, K (Bennett, Kathleen); Kenny, RA (Kenny, Rose Anne)  
Year 2012
Journal JOURNAL OF CLINICAL ONCOLOGY 
Publication Type Original Article 

Article Title Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting
Authors Cregg, PJ (Cregg, P. J.); Murphy, K (Murphy, Kieran); Mardinoglu, A (Mardinoglu, Adil) 
Year 2012
Journal APPLIED MATHEMATICAL MODELLING
Publication Type Original Article

Article Title Assessing Patients’ Beliefs About Their Cancer-Related Fatigue: Validation of an Adapted Version of the Illness Perception Questionnaire. 
Authors Pertl, M., Hevey, D., Donohoe, G., & Collier, S. 
Year 2012
Journal Journal of Clinical Psychology in Medical Settings
Publication Type Original Article

Article Title Bacterial vectors for imaging and cancer gene therapy: a review.
Authors Cronin M, Stanton RM, Francis KP, Tangney M.
Year 2012
Journal Cancer Gene Ther.
Publication Type Review

Article Title Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth
Authors Kelly, GM (Kelly, Geraldine M.); Buckley, DA (Buckley, Deirdre A.); Kiely, PA (Kiely, Patrick A.); Adams, DR (Adams, David R.); O'Connor, R (O'Connor, Rosemary) 
Year 2012
Journal JOURNAL OF BIOLOGICAL CHEMISTRY
Publication Type Original Article

Article Title Direct Interaction between Scaffolding Proteins RACK1 and 14-3-3 zeta Regulates Brain-derived Neurotrophic Factor ( BDNF) Transcription
Authors Neasta, J (Neasta, Jeremie); Kiely, PA (Kiely, Patrick A.); He, DY (He, Dao-Yao); Adams, DR (Adams, David R.); O'Connor, R (O'Connor, Rosemary); Ron, D (Ron, Dorit) 
Year 2012
Journal JOURNAL OF BIOLOGICAL CHEMISTRY 
Publication Type Original Article

Article Title Rab11 proteins in health and disease.
Authors Kelly EE, Horgan CP, McCaffrey MW.
Year 2012
Journal Biochem Soc Trans.
Publication Type Review

Article Title The Rab family of proteins: 25 years on. 
Authors Kelly EE, Horgan CP, Goud B, McCaffrey MW.
Year 2012
Journal Biochem Soc Trans.
Publication Type Review

Article Title Centrifugal microfluidics for cell analysis. 
Authors Burger R, Kirby D, Glynn M, Nwankire C, O'Sullivan M, Siegrist J, Kinahan D, Aguirre G, Kijanka G, Gorkin RA 3rd, Ducrée J.
Year 2012
Journal Curr Opin Chem Biol. 
Publication Type Review

Article Title Array-based capture, distribution, counting and multiplexed assaying of beads on a centrifugal microfluidic platform. 
Authors Burger R, Reith P, Kijanka G, Akujobi V, Abgrall P, Ducrée J.
Year 2012
Journal Lab Chip.
Publication Type Original Article 

Article Title Acute intestinal failure in surgical patients: an audit of incidence, management and outcomes in an irish hospital, and compliance with ASGBI guidelines.
Authors Geoghegan AR, Donohoe CL, Reynolds JV.
Year 2012
Journal Ir J Med Sci.
Publication Type Original Article 


Brain Cancer (3)

Article Title Comparative genomic and proteomic analysis of high grade glioma primary cultures and matched tumor in situ
Authors Howley, R (Howley, R.); Kinsella, P (Kinsella, P.); Buckley, PG (Buckley, P. G.); Alcock, L (Alcock, L.); Jansen, M (Jansen, M.); Heffernan, J (Heffernan, J.); Stallings, RL (Stallings, R. L.); Brett, FM (Brett, F. M.); Amberger-Murphy, V (Amberger-Murphy, V.); Farrell, MA (Farrell, M. A.)
Year 2012
Journal EXPERIMENTAL CELL RESEARCH 
Publication Type Original Article 

Article Title MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-beta signalling pathway
Authors Lynch, J (Lynch, Jennifer); Fay, J (Fay, Joanna); Meehan, M (Meehan, Maria); Bryan, K (Bryan, Kenneth); Watters, KM (Watters, Karen M.); Murphy, DM (Murphy, Derek M.); Stallings, RL (Stallings, Raymond L.) 
Year 2012
Journal CARCINOGENESIS
Publication Type Original Article 

Article Title Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib 
Authors Kinsella, P (Kinsella, Paula); Howley, R (Howley, Rachel); Doolan, P (Doolan, Padraig); Clarke, C (Clarke, Colin); Madden, SF (Madden, Stephen F.); Clynes, M (Clynes, Martin); Farrell, M (Farrell, Michael); Amberger-Murphy, V (Amberger-Murphy, Verena) 
Year 2012
Journal EXPERIMENTAL CELL RESEARCH
Publication Type Original Article 


Breast Cancer (3)

Article Title MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells
Authors Selcuklu, SD (Selcuklu, S. Duygu); Donoghue, MTA (Donoghue, Mark T. A.); Rehmet, K (Rehmet, Kristina); Gomes, MD (Gomes, Matheus de Souza); Fort, A (Fort, Antoine); Kovvuru, P (Kovvuru, Prasad); Muniyappa, MK (Muniyappa, Mohan K.); Kerin, MJ (Kerin, Michael J.); Enright, AJ (Enright, Anton J.); Spillane, C (Spillane, Charles) 
Year 2012
Journal JOURNAL OF BIOLOGICAL CHEMISTRY
Publication Type Original Article 

Article Title Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells
Authors Selcuklu, SD (Selcuklu, S. Duygu); Donoghue, MTA (Donoghue, Mark T. A.); Kerin, MJ (Kerin, Michael J.); Spillane, C (Spillane, Charles) 
Year 2012
Journal BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
Publication Type Original Article 

Article Title The peptidyl prolyl isomerase cyclophilin A localizes at the centrosome and the midbody and is required for cytokinesis
Authors Bannon, JH (Bannon, John H.); O'Donovan, DS (O'Donovan, Darragh S.); Kennelly, SME (Kennelly, Susan M. E.); Mc Gee, MM (Mc Gee, Margaret M.)
Year 2012
Journal CELL CYCLE
Publication Type Original Article


Colorectal Cancer (1)

Article Title A reverse-ELISA for the detection of TRIM28/KAP1 serum autoantibodies in colorectal cancer patients
Authors Hector S, Chen H, Kijanka G, Murray F, Prehn JH.
Year 2012
Journal Acta Oncol.
Publication Type Letter


Gastrointestinal Cancer (1)

Article Title Gastric Neuroendocrine Tumours.
Authors Crosby DA, Donohoe CL, Fitzgerald L, Muldoon C, Hayes B, O'Toole D, Reynolds JV.
Year 2012
Journal Dig Surg.
Publication Type Original Article 


Leukaemia (3)

Article Title H2O2 Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling  
Authors Woolley, JF (Woolley, John F.); Naughton, R (Naughton, Ruth); Stanicka, J (Stanicka, Joanna); Gough, DR (Gough, David R.); Bhatt, L (Bhatt, Lavinia); Dickinson, BC (Dickinson, Bryan C.); Chang, CJ (Chang, Christopher J.); Cotter, TG (Cotter, Thomas G.) 
Year 2012
Journal PLOS ONE
Publication Type Original Article

Article Title Redox regulated growth factor Survival signalling.
Authors Woolley JF, Corcoran A, Groeger G, Landry WD, Cotter TG.
Year 2012
Journal Antioxid Redox Signal.
Publication Type Review

Article Title The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells.
Authors Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM.
Year 2012
Journal Int J Oncol.
Publication Type Original Article


Lung Cancer (1)

Article Title COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention
Authors Cathcart MC, O'Byrne KJ, Reynolds JV, O'Sullivan J, Pidgeon GP.
Year 2012
Journal Biochim Biophys Acta
Publication Type Review


Oesophageal Cancer (11)

Article Title Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer
Authors Picardo SL, Maher SG, O'Sullivan JN, Reynolds JV.
Year 2012
Journal Dig Surg. 
Publication Type Review

Article Title Evidence-based selective application of transhiatal esophagectomy in a high-volume esophageal center. 
Authors Donohoe CL, O'Farrell NJ, Ravi N, Reynolds JV.
Year 2012
Journal World J Surg.
Publication Type Original Article 

Article Title IGF-1 and Its Receptor in Esophageal Cancer: Association with Adenocarcinoma and Visceral Obesity
Authors Suzanne L Doyle, Claire L Donohoe, Stephen P Finn, Julia M Howard, Fiona E Lithander, John V Reynolds, Graham P Pidgeon and Joanne Lysaght
Year 2012
Journal The American Journal of Gastroenterology
Publication Type Original Article 

Article Title Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma.
Authors Donohoe CL, Doyle SL, McGarrigle S, Cathcart MC, Daly E, O'Grady A, Lysaght J, Pidgeon GP, Reynolds JV.
Year 2012
Journal Br J Surg.
Publication Type Original Article 

Article Title Evolving progress in oncologic and operative outcomes for esophageal and junctional cancer: lessons from the experience of a high-volume center.
Authors Reynolds JV, Donohoe CL, McGillycuddy E, Ravi N, O'Toole D, O'Byrne K, Hollywood D.
Year 2012
Journal J Thorac Cardiovasc Surg.
Publication Type Original Article 

Article Title Defining a Successful Esophagectomy.
Authors Donohoe CL, Reynolds JV.
Year 2012
Journal Ann Surg.
Publication Type Letter

Article Title The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells
Authors Nyhan, MJ (Nyhan, M. J.); O'Donovan, TR (O'Donovan, T. R.); Elzinga, B (Elzinga, B.); Crowley, LC (Crowley, L. C.); O'Sullivan, GC (O'Sullivan, G. C.); McKenna, SL (McKenna, S. L.) 
Year 2012
Journal BRITISH JOURNAL OF CANCER
Publication Type Original Article 

Article Title Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer 
Authors Picardo SL, Maher SG, O'Sullivan JN, Reynolds JV.
Year 2012
Journal Review Dig Surg. 
Publication Type Review

Article Title MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma. 
Authors Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG.
Year 2012
Journal J Mol Med (Berl).
Publication Type Original Article 

Article Title Radiation sensitivity of esophageal adenocarcinoma: the contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance. 
Authors Hötte GJ, Linam-Lennon N, Reynolds JV, Maher SG.
Year 2012
Journal Radiat Res.
Publication Type Original Article 

Article Title Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma
Authors Donohoe CL, Doyle SL, McGarrigle S, Cathcart MC, Daly E, O'Grady A, Lysaght J, Pidgeon GP, Reynolds JV.
Year 2012
Journal Br J Surg.
Publication Type Original Article


Ovarian Cancer (3)

Article Title Resistance to Paclitaxel in a Cisplatin-Resistant Ovarian Cancer Cell Line Is Mediated by P-Glycoprotein
Authors Stordal, B (Stordal, Britta); Hamon, M (Hamon, Marion); McEneaney, V (McEneaney, Victoria); Roche, S (Roche, Sandra); Gillet, JP (Gillet, Jean-Pierre); O'Leary, JJ (O'Leary, John J.); Gottesman, M (Gottesman, Michael); Clynes, M (Clynes, Martin) 
Year 2012
Journal PLOS ONE
Publication Type Original Article 

Article Title Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer
Authors Furlong, F (Furlong, Fiona); Fitzpatrick, P (Fitzpatrick, Patricia); O'Toole, S (O'Toole, Sharon); Phelan, S (Phelan, Sine); McGrogan, B (McGrogan, Barbara); Maguire, A (Maguire, Aoife); O'Grady, A (O'Grady, Anthony); Gallagher, M (Gallagher, Michael); Prencipe, M (Prencipe, Maria); McGoldrick, A (McGoldrick, Aloysius); McGettigan, P (McGettigan, Paul); Brennan, D (Brennan, Donal); Sheils, O (Sheils, Orla); Martin, C (Martin, Cara); Kay, EW (Kay, Elaine W.); O'Leary, J (O'Leary, John); McCann, A (McCann, Amanda) 
Year 2012
Journal JOURNAL OF PATHOLOGY 
Publication Type Original Article 

Article Title Eukaryotic DNA damage checkpoint activation in response to double-strand breaks
Authors Finn, K (Finn, Karen); Lowndes, NF (Lowndes, Noel Francis); Grenon, M (Grenon, Muriel)
Year 2012
Journal CELLULAR AND MOLECULAR LIFE SCIENCES 
Publication Type Review


Prostate Cancer (8)

Article Title "True" Antiandrogens-Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor-Coactivator Interactions: Novel Tools for Prostate Cancer 
Authors Caboni, L (Caboni, Laura); Kinsella, GK (Kinsella, Gemma K.); Blanco, F (Blanco, Fernando); Fayne, D (Fayne, Darren); Jagoe, WN (Jagoe, William N.); Carr, M (Carr, Miriam); Williams, DC (Williams, D. Clive); Meegan, MJ (Meegan, Mary J.); Lloyd, DG (Lloyd, David G.) 
Year 2012
Journal JOURNAL OF MEDICINAL CHEMISTRY 
Publication Type Original Article 

Article Title The effect of short term neo-adjuvant androgen deprivation on erectile function in patients treated with external beam radiotherapy for localised prostate cancer: An analysis of the 4-versus 8-month randomised trial (Irish Clinical Oncology Research Group 97-01)
Authors Daly, PE (Daly, Patricia E.); Dunne, MT (Dunne, Mary T.); O'Shea, CM (O'Shea, Carmel M.); Finn, MA (Finn, Marie A.); Armstrong, JG (Armstrong, John G.) 
Year 2012
Journal RADIOTHERAPY AND ONCOLOGY
Publication Type Original Article 

Article Title Breast and Prostate Cancer Productivity Costs: A Comparison of the Human Capital Approach and the Friction Cost Approach
Authors Hanly, P (Hanly, Paul); Timmons, A (Timmons, Aileen); Walsh, PM (Walsh, Paul M.); Sharp, L (Sharp, Linda) 
Year 2012
Journal VALUE IN HEALTH
Publication Type Original Article 

Article Title Overcoming antibody expression and screening limitations by smart design: Applications to PSA immunoassay development
Authors Hayes, CJ (Hayes, C. J.); Leonard, P (Leonard, P.); O'Kennedy, R (O'Kennedy, R.) 
Year 2012
Journal PROTEIN EXPRESSION AND PURIFICATION
Publication Type Original Article 

Article Title The identification and internal validation of a preoperative serum biomarker panel to determine extracapsular extension in patients with prostate cancer
Authors Oon, SF (Oon, Sheng F.); Fanning, DM (Fanning, Deirdre M.); Fan, Y (Fan, Yue); Boyce, S (Boyce, Susie); Murphy, TB (Murphy, T. Brendan); Fitzpatrick, JM (Fitzpatrick, John M.); Watson, RW (Watson, R. William) 
Year 2012
Journal PROSTATE
Publication Type Original Article 

Article Title Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer.
Authors Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, Barrett C, Loftus B, Thornhill J, Hewitt SM, Lawler M, Kay E, Lynch T, Hollywood D.
Year 2012
Journal Int J Cancer. 
Publication Type Original Article 

Article Title Gene expression analysis in prostate cancer: The importance of the endogenous control.
Authors Vajda A, Marignol L, Barrett C, Madden SF, Lynch TH, Hollywood D, Perry AS.
Year 2012
Journal PROSTATE
Publication Type Original Article 

Article Title IGFBP7 promoter methylation and gene expression analysis in prostate cancer.
Authors Sullivan L, Murphy TM, Barrett C, Loftus B, Thornhill J, Lawler M, Hollywood D, Lynch T, Perry AS.
Year 2012
Journal J Urol.
Publication Type Original Article