Exploring the link between obesity and oesophageal adenocarcinoma: the role of STAT3 inhibition

Key Information

Cancer type: 
Research Institution: 
TCD & St James's
Grant Amount: 
Start date: 
October 2, 2012
End date: 
September 30, 2016

Scientific Project Abstract

This project aims to identify new biomarkers which may help in the early detection of colon cancer. A group of enzymes called PKC kinases have been shown to play a role in colon cancer progression and it is thought that changes in the activity and subcellular localisation of these enzymes plays a role in conversion of normal colon cells to cancerous colon cells. The aim of this project is to identify if this change in activity and localisation of PKC kinases could be used as a marker of early colon cancer detection.

For the non-scientist

One-line description: 
Determining how molecules released by fat cells can cause oesophageal cancer
What this project involves: 

Overweight and obese people are twice as likely as people of healthy weight to develop oesophageal cancer, however the mechanism as to why this occurs is not well understood. This project will investigate if factors released by fat cells can lead to the development of abnormal cancer cell growth and it will identify proteins in the cancer cells which are directly responding to the factors released by the fat cells. If proteins responding to these factors can be identified, they may represent potential drug targets for treating oesophageal cancer.