Cardiac Glycosides and Prostate Cancer Incidence, Outcomes

Key Information

Cancer type: 
Prostate
Research Institution: 
Trinity & St James's
Grant Amount: 
€86,554
Start date: 
October 11, 2010
End date: 
October 10, 2013

Scientific Project Abstract

Prostate cancer is the most common cancer in Irish men and the second most common cause of cancer death. Laboratory studies have suggested that digoxin, a drug obtained from the digitalis plant and commonly used for the treatment of heart conditions, may have a role to play in the prevention and treatment of prostate cancer. Other studies have proposed that aspirin use may be associated with reduced risk of cancer death. This research has investigated, in a cohort of Irish prostate cancer patients, whether men receiving digoxin or aspirin had improved outcomes compared to men who didn't receive these medicines. 

For the non-scientist

One-line description: 
Investigating the role of aspirin or digoxin on prostate cancer patient outcomes
What this project involves: 

Prostate cancer is a disease for which there is few effective treatment options. Recent studies have identified that two commonly utilised and commercially available drugs, namely digoxin and aspirin, may play a role in the prevention of prostate cancer. This project aims to further examine the preventive nature of these two drugs in prostate cancer patients and determine if taking digoxin or aspirin has any effect on the number of prostate cancer deaths.