Hormone Therapy for advanced prostate cancer

Hormone therapy is the first treatment used to control advanced prostate cancer. Prostate cancer depends on the male hormone testosterone to grow. By reducing the amount of testosterone in your body the growth of cancer cells can be slowed or stopped.

Most men with advanced prostate cancer will stay on hormone therapy for the rest of their lives, although for some men it is possible to take hormone therapy now and then. This is called intermittent hormone therapy.

Hormone therapy can work well for years. During this time, you will have regular check-ups and your doctor will watch your response to treatment. He or she will check any symptoms and examine you as well. Your PSA level will be measured too.  The PSA test is used as a guide to the success of the treatment. 

How does hormone therapy work?

Hormones are made naturally in your body and control how normal cells grow and work. Testosterone is a male hormone, or androgen, that controls the growth and development of male sexual organs and also your sex drive (libido). Most testosterone is made in your testicles and a small amount by your adrenal glands near your kidneys.

The growth of prostate cancer cells can be driven by testosterone. By reducing the amount of testosterone in your body, or by blocking it from getting to the prostate cancer cells, prostate cancer can be slowed down or stopped.

Hormone therapy used in the treatment of advanced prostate cancer can treat prostate cancer cells wherever they are in the body, such as in your bone. Another name for hormone treatment is androgen deprivation therapy. Androgens are male hormones, so androgen deprivation means stopping or blocking the action of male hormones in your body.

What are the types of hormone therapy?

There are three main types of hormone therapy that can either stop your body making testosterone or block the effects of it on prostate cancer cells:

  • Injections or implants to stop your body making testosterone

  • Tablets to stop the effect of testosterone. These are known as anti-androgens

  • Surgery to remove the testicles


Some drugs ‘turn off’ the making of male hormones in your testicles. The drugs commonly used include goserelin (Zoladex®), leuprorelin (Prostap®) triptorelin (Decapeptyl®), leuprorelin acetate (Eligard®) and degarelix (Firmagon®). These drugs are injected as a pellet or liquid under your skin or into a muscle. Injections can be given once a month or every 3 or 6 months.

The amount of hormone therapy you get is the same whether you have the injection every 1,3 or 6 months or the implant once a year, as some of the injections are ‘slow release’ and give you the medication slowly over a longer period of time. For some men this saves trips to the GP . You can talk to your doctor or nurse about this if you wish to.

Starting injection hormone therapy

When you start taking hormone therapy you will be asked to take anti-androgen tablets for a week or two before your first injection (unless you have Firmagon®). This is because your body’s first response to the injection is to try to make more testosterone. This could make your cancer grow more quickly and is known as ‘tumour flare’.

The tablets block the effect of the testosterone on the cancer cells and stop it causing you harm. Your doctor will prescribe anti-androgen tablets for some time before and after starting injection treatment.

Anti-androgen tablets

Other hormone drugs can block testosterone from entering your prostate cancer cells. This prevents the cancer cells from growing. These drugs are called anti-androgens. Common ones are flutamide (Drogenil®), bicalutamide (Casodex®) and cyproterone acetate (Androcur®). 

Combination therapy or maximal androgen blockade

Hormone injections or tablets can be given on their own. Sometimes a combination of the injections and tablets may be used. This is known as combination therapy or complete androgen blockade (CAB) or maximum androgen blockade (MAB).

Combination therapy prevents testosterone from being made in your testicles and also blocks small amounts made by your adrenal glands from working on prostate cancer cells.

For more information, you can view our film on Hormone Therapy and Prostate Cancer.

Call the Cancer Nurseline on 1800 200 700 to speak with a cancer nurse specialist or visit our section Hormone Therapy and Prostate CancerYou can also get a copy from a Daffodil Centre if there is one located in the hospital you are attending.

Surgical hormone therapy

Most testosterone is made in your testicles, so removing them will block the release of testosterone straight away. Surgery to remove your testicles is known as an orchidectomy. It is done through a small cut in your scrotum. The scrotum is the sac that holds your testicles. Very occasionally men choose this option, but this type of surgery is not used very often any more as many men find the idea of this operation very distressing. Your doctor and nurse will give you more advice, if you opt for this treatment.

What are the side-effects of hormone therapy? 

The common side-effects of hormone therapy include:

Sexual side-effects

Hormone therapy can affect your interest in sex, known as your libido, and also your ability to get an erection. You could discuss your concerns with your partner and get advice from your doctor, nurse or a professional psychosexual counsellor.

Medications, injections and vacuum devices that may help with impotence are available. Often the decline in libido can reduce your interest in treatment for erectile dysfunction. This is quite common. If you can, discuss this with your partner so you both can come to an agreement about what is important to you. Your doctor will advise you about which treatment is best for you.

You will find that your testicles become smaller in size once you have been on hormone therapy injections for a while.

For further information please read our factsheet Sex, Erectile Dysfunction and Prostate Cancer .

You can call the Cancer Nurseline Freephone 1800 200 700 if you would like a copy to be posted or if you wish to speak with a specialist cancer nurse confidentially. 

You could also visit your local Daffodil Centre if there is one in the hospital you attend. 

You can also read further information about sex and prostate cancer. 

Hot flushes

Hot flushes and sweating happen because the lack of testosterone affects the part of your brain that regulates heat. Speak to your doctor if they are troubling you, as medication may be prescribed. Speak to your doctor if they are troubling you, as medication may be prescribed. Read some tips on coping with hot flushes.

Weight gain

Hormone therapy may affect your weight, particularly around your waist. You might also lose some of your muscle tone and strength. Taking regular exercise will help you to stay a healthy weight, help prevent loss of muscle and bone strength and is also good for your heart. A healthy diet can help you to stay a healthy weight. You can get further advice from your doctor or call our Cancer Nurseline on Freephone 1800 200 700 or visit a Daffodil Centre. 


Hormone therapy can cause fatigue or extreme tiredness for some men. If you are troubled by tiredness, talk to your doctor so that he or she can rule out other causes of fatigue. 

You might find that taking regular exercise helps you to manage your tiredness, gives you more energy and helps you to cope.

For further information about fatigue download our booklet Coping with Fatigue.

You can also call our Cancer Nurseline on 1800 200 700 to request a copy or to speak confidentially with a cancer nurse specialist. You can also visit your local Daffodil Centre if there is one in the hospital you attend.

Mood changes

Testosterone affects how your mind works. When there is less testosterone in your body you might get mood changes, poor concentration or memory problems, anxiety and sometimes depression. Some men may feel more aware of their emotional side and may find that they may cry more easily than before they were on the hormone treatment. 

Some therapies, like relaxation therapy, meditation or yoga, might help you to cope with these frustrating symptoms. Discuss your concerns with your doctor or nurse who might refer you to a professional counsellor. You could also visit your local community based cancer support centre where you may have the opportunity to meet others, join groups and/or arrange a ‘one-to-one’ appointment with a professional counsellor. Click here for details on support available.

For further information about coping with short-term memory loss and concentration visit our short term memory loss and cancer page.

Breast swelling and tenderness

Tenderness or swelling in the breast (also known as gynaecomastia) can occur if you are given hormone therapy. It occurs more commonly with anti-androgen therapy. It can vary from mild tenderness, with or without mild swelling, to a more noticeable amount of tissue growth around the breast area.

Medications like tamoxifen can help relieve this side-effect. If this side-effect concerns you then mention it to your doctor or nurse.  

Osteoporosis or bone thinning

Hormone therapy affects how your bones are normally formed and can lead to osteoporosis. This means that bones can be less dense and become brittle, making them more prone to fractures (breaking). Smoking and drinking excessive alcohol increases your risk of osteoporosis.

Taking exercise such as daily walks and eating foods rich in vitamin D and calcium can help to prevent osteoporosis. You can get calcium from dairy products such as cheese, milk and yoghurt and also from tinned fish such as sardines and salmon. Calcium is also found in broccoli and leafy green vegetables. Your body needs vitamin D to work with the calcium so it is important to include this in your diet as well. 

Osteoporosis has no symptoms: the first sign is often a broken bone, so it is important to do what you can to prevent osteoporosis developing.

You should talk to your doctor or nurse for advice or visit www.irishosteoporosis.ie or call the Irish Osteoporosis Society on Lo-Call 1890 252 751. 

Our Bone Health factsheet explains the causes of bone loss and treatments available. It also gives tips on avoiding broken bones and ways to improve the health of your bones. 

How will I know my hormone therapy is working?

Your doctor will monitor your PSA level once you are on hormone therapy. Because hormone therapy stops the growth of prostate cancer cells, your PSA usually falls when you start hormone therapy. This is how your doctor will measure your response to the treatment. 

Hormone therapy usually controls prostate cancer growth for many months or years. It is difficult for doctors to tell you how long it is expected to work for because it depends on a number of things such as how much cancer is present and the grade of your cancer.  

If your PSA goes up on a few occasions, it may be a sign that your hormone therapy is not keeping the cancer under control as well as it had been. The doctor will discuss with you other treatments that may be available after hormone therapy.

You can download our booklet Understanding advanced (metastatic) prostate cancer. Or if you prefer you can pick one up in your local Daffodil Centre if there is one in the hospital you are attending. 

Date Last Reviewed: 
Monday, July 16, 2018