Irish Cancer Society - Dedicated to preventing cancer and saving lives from cancer

Research Projects funded by Cancer Research Ireland

Projects are listed below in alphabetical order based on cancer type.
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Total Number of Projects:

Project Title	A Continuous Professional Development Framework for Professionals and Volunteers Working with People Affected by Cancer....[more]
Cancer Type	All Cancers	Keywords	Psycho-oncology, Education, Health care professionals, Volunteers
Project Type	Education and Communication	Investigators	Scott
Project Code	PSY04SCO	Centre	School of Nursing, Dublin City University.

Project Title	Functional screen for miRNAs regulating oncogenesis or tumor suppression in human cells...[more]
Cancer Type	All Cancers	Keywords	epigenetics, cancer, microRNA, oncogenes, tumor suppressors
Project Type	Cancer Initiation: Oncogenes and Tumor Suppressor Genes	Investigators	Spillane
Project Code	CRI04SPI	Centre	Biosciences Institute, Dept of Biochemistry, University College Cork, Ireland

Project Title	E-cadherin promoter methylation status and c-MET/HGF expression levels in transitional cell carcinoma of the bladder...[more]
Cancer Type	Bladder Cancer	Keywords	E-cadherin, Methylation, TaqMan Real time PCR, EMT; Epithelial Mesenchynal Transition, TCC; Transitional cell carcinoma of the Bladder,
Project Type	Basic laboratory	Investigators	Amanda McCann
Project Code	CRI03MCC	Centre	National University of Ireland, Dublin

Project Title	Epithelial Mesenchymal Transition (EMT) markers as predictors of recurrence in transitional cell carcinoma (TCC) of the bladder...[more]
Cancer Type	Bladder Cancer	Keywords	EMT; Epithelial Mesenchynal Transition, TCC; Transitional cell carcinoma of the Bladder, HMGA2, 14-3-3-delta
Project Type	Cancer Progression and Metastasis	Investigators	Amanda McCann
Project Code	CRI04MCC	Centre	Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4

Project Title	Understanding molecular influences on disease classification and response to therapy in haematological malignancy...[more]
Cancer Type	Blood Cancer	Keywords	lymphoma, gene profiling, biomarkers of response
Project Type	Technology Development and/or Marker Discovery	Investigators	Mark Lawler
Project Code	CRI04LAW	Centre	Durkan Research Laboratories, Institute of Molecualr Medicine, St James's Hospital

Project Title	Open Windows...[more]
Cancer Type	Bone Marrow Transplantation	Keywords	Isolation, quality of life, communication, psycho-oncology
Project Type	Patient Care and Survivorship Issues	Investigators	Shaun McCann
Project Code	PSY04MCC	Centre	Denis Burkitt Unit, St. James Hospital, Dublin 8

Project Title	Mammaglobin as a marker for breast cancer...[more]
Cancer Type	Breast Cancer	Keywords
Project Type	Basic laboratory	Investigators	Michael Joe Duffy
Project Code	CRI03DUF	Centre	St. Vincent's University Hospital, Dublin 4

Project Title	Functional genomics of breast cancer...[more]
Cancer Type	Breast Cancer	Keywords	Breast cancer, metastasis, biomarkers, tissue microarrays, automated analysis
Project Type	Laboratory	Investigators	William Gallagher
Project Code	CR102GAL	Centre	National University of Ireland, Dublin

Project Title	Insulin-like growth factor binding protein 4 in breast cancer and metastasis...[more]
Cancer Type	Breast Cancer	Keywords	Metastasis, Angiogenesis, Proliferation
Project Type	Laboratory	Investigators	Judith Harmey
Project Code	CRI02HAR	Centre	Beaumont Hospital

Project Title	Genetic Determinants of Progression of DCIS to Invasive Breast Cancer...[more]
Cancer Type	Breast Cancer	Keywords	genes; oncogenesis: DCIS; tunour progression; array CGH; expression arrays
Project Type	Cancer Initiation: Oncogenes and Tumor Suppressor Genes	Investigators	Peter Dervan
Project Code	CRI04DER	Centre	Eccles Breast Screening Unit / Mater Hospital & The Conway Institute of Biomolecular and Biomedical Research

Project Title	Molecular mechanisms of Survivin regulation in breast cancer...[more]
Cancer Type	Breast Cancer	Keywords	Breast cancer, survivin, myc
Project Type	Cancer Related Biology	Investigators	Young
Project Code	CRI02YOU	Centre	Conway Institute, UCD, Dublin 4

Project Title	Identification of IGF-I related genes that control survival and transformation ...[more]
Cancer Type	Breast, lung, prostate	Keywords
Project Type	Basic Research	Investigators	Rosemary OConnor
Project Code		Centre	NUIC

Project Title	Endothelium as a target in the design of novel inhibitors of tumour angiogenesis / vasculature....[more]
Cancer Type	Cancer Biology	Keywords	Tumour angiogenesis / vasculature, Tubulin Inhibitors, Aminopeptidase N, Vasculature shutdown
Project Type	Laboratory	Investigators	John Walsh
Project Code	CRI03WAL	Centre	Trinity College Dublin

Project Title	Heat shock protein-based tumour vaccines: Potentiation of responses through priming....[more]
Cancer Type	Cancer Immunology	Keywords	Immunotherapy
Project Type	Laboratory	Investigators	Deirdre Toomey
Project Code	CRI03TOO	Centre	Royal College of Surgeons in Ireland

Project Title	New strategies for tumour treatment using the Semliki virus vector...[more]
Cancer Type	Cancer Immunology	Keywords	Semliki Forest virus, Viral vector, Gene therapy, Animal models, Viral oncolysis
Project Type	Laboratory	Investigators	Gregory Atkins
Project Code	CRI02ATK	Centre	Moyne Institute - Trinity College Dublin

Project Title	NK cells, HLA class I and bone marrow transplantation...[more]
Cancer Type	Cancer Immunology	Keywords
Project Type	Laboratory	Investigators	Clair Gardiner
Project Code		Centre	Trinity College Dublin

Project Title	Evaluating the effectiveness of a therapeutic recreation family programme in reducing the psychosocial impact of childhood cancer....[more]
Cancer Type	Childrens Cancers	Keywords	Family support, Evaluation
Project Type	Complementary and Alternative Treatment Approaches	Investigators	Suzanne Guerin
Project Code	PSY04GUE	Centre	Dept. of Psychology, University College Dublin

Project Title	What is the leukocyte protein L-Plastin doing in colon cancer cells?...[more]
Cancer Type	Colon & Rectal Cancer	Keywords	L-plastin, E-cadherin, Integrin, Metastasis, Epithelium
Project Type	Cancer Progression and Metastasis	Investigators	Long
Project Code	CRI04LON	Centre	Dept of Biochemistry, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland

Project Title	Role of Telomeres & Telomerase in Colorectal Cancer Development, Progression & Metastasis...[more]
Cancer Type	Colon & Rectal Cancer, Gastrointestinal Tract	Keywords	Colorectal Cancer, telomeres, telomerase
Project Type	Cancer Progression and Metastasis	Investigators	Jacinta O'Sullivan
Project Code	CRI04OSUJ	Centre	Education & Research Centre & Centre for Colorectal Disease, St Vincent's University Hospital, Dublin 4

Project Title	Advanced applied analysis of cancer chemotherapeutic agents...[more]
Cancer Type	Drug Enhancement	Keywords	Cancer chemotherapy, LC-MS, anthracyclines, taxanes, HPLC, Phase I clinical trial, treatment individualisation
Project Type	Translational	Investigators	Robert OConnor
Project Code	CRI03OCO	Centre	NCIB- Dublin City University

Project Title	Novel targets in tumour dissemination...[more]
Cancer Type	General	Keywords
Project Type	Basic Research	Investigators	Dermot Kenny
Project Code		Centre	RCSI

Project Title	Reactive oxygen species in apoptosis...[more]
Cancer Type	General cancer application	Keywords	Reactive oxygen species, Protein oxidation, Proteomics, Antioxidants, Chemotherapy
Project Type	Basic laboratory	Investigators	Karen England
Project Code	CRI03ENG	Centre	Department of Biochemistry, NUI Cork

Project Title	Genome wide investigation of head and neck squamous cell carcinoma in young patients...[more]
Cancer Type	Head & Neck Cancer, Oral Cavity & Lip Cancer	Keywords	head and neck cancer, young, nonsmokers
Project Type	Cancer Initiation: Alterations in Chromosomes	Investigators	O'Regan
Project Code	CRI02ORE	Centre	Department of Histopathology, IMM, Trinity Centre for Health Sciences, St. James Hospital, James St, Dublin 8

Project Title	Bfl-1/A1 expression and potential role in Hodgkin's Disease and Post-Transplant Lymphoproliferative Disease...[more]
Cancer Type	Hodgkins Disease / Lymphoma	Keywords	Hodgkins Lymphoma, Post-transplant lymphoproliferative disease, Epstein-Barr virus, apoptosis
Project Type	Cancer Initiation: Oncogenes and Tumor Suppressor Genes	Investigators	Dermot Walls
Project Code	CRI02WAL	Centre	School of Biotechnology and National Centre for Sensor Research, Faculty of Science and Health, Dublin City University, Dublin 9

Project Title	To elucidate the role of CD28 in cancer progression...[more]
Cancer Type	Hodgkins Disease / Lymphoma Sarcoma, Rhabdomyosarcoma, Childhood	Keywords	Rhabdomyosarcoma, EphA3, tyrosine kinase receptors
Project Type	Cancer Progression and Metastasis	Investigators	Loraine Smith
Project Code	CRI02SMI	Centre	Biosciences Institute, National University of Ireland, Cork

Project Title	Gene expression analysis in chronic myelocitic leukaemia...[more]
Cancer Type	Leukaemia	Keywords
Project Type	Basic Research	Investigators	Sharon McKenna
Project Code		Centre	NUIC

Project Title	Protease profiling in early colorectal cancer and its association with chromosomal abnormalities, anatomical stage and clinical progression....[more]
Cancer Type	Leukaemia	Keywords
Project Type	Laboratory	Investigators	Hugh Mulcahy
Project Code	CRI03MUL	Centre	St. Vincent's University Hosiptal

Project Title	Correlation between angiogenesis and CD38 expression in B-cell CLL...[more]
Cancer Type	Leukaemia	Keywords
Project Type	Laboratory research	Investigators	Robert OConnor
Project Code		Centre	Beaumont

Project Title	Investigation of beta-galactoside binding protein as an anti-leukaemic agent...[more]
Cancer Type	Leukaemia	Keywords
Project Type	Laboratory	Investigators	Mark Lawler
Project Code	CRI02LAW	Centre	Trinity College Dublin & St. James's Hospital

Project Title	Investigation of the mechanisms of radiation induced by-stander effects and their relevance for cancer therapy...[more]
Cancer Type	Leukaemia, bladder and prostate cancers	Keywords
Project Type	Basic Research	Investigators	Brian McMurry
Project Code		Centre	DIT

Project Title	A strategy to quantify and reduce geometric uncertainty to improve the therapeutic ratio of radiation for lung cancer...[more]
Cancer Type	Lung cancer	Keywords
Project Type	Clinical Trial	Investigators	John Armstrong
Project Code	CRI03ARM	Centre	St. Luke's Hospital, Rathgar, Dublin 6

Project Title	Protein tyrosine phosphatases in human melanoma genesis, a functional study using genetic suppressor elements....[more]
Cancer Type	Melanoma	Keywords	melanoma ptp melanocyte gse
Project Type	Cancer Initiation: Oncogenes and Tumor Suppressor Genes	Investigators	David Easty
Project Code	CRI02EAS	Centre	Conway Institute, UCD, Belfield, Dublin 4

Project Title	Molecular epidemiology of myeloma - influence of DNA repair genes...[more]
Cancer Type	Myeloma	Keywords	Multiple Myeloma, DNA Repair, Genetics, SNPs
Project Type	Laboratory	Investigators	Mark Lawler
Project Code	CRI03LAW	Centre	Trinity College Dublin & St. James Hospital

Project Title	Deciphering the common promoters of upper gastrointestinal cancers...[more]
Cancer Type	Oesophagal, stomach	Keywords	Genbe expression,upper GI cancer
Project Type	Basic laboratory	Investigators	Peter Doran
Project Code	CRI03DOR	Centre	Department of Medicine, Mater Hospital, Dublin 7

Project Title	Analysis of Vitamin C in the chemoprevention of oesophageal adenocarcinoma and as a modulator of sensitivity to chemotherapy and radiation therapy....[more]
Cancer Type	Oesophageal	Keywords	Vitamin C, NF-kB, Inflammation, Barrett's oesophagus, Chemothradiotherapy, Oesophageal cancer
Project Type	Laboratory	Investigators	John Reynolds
Project Code	CRI03REY	Centre	St. James's Hospital

Project Title	Induction of chemosensitivity in oesophageal tumours through addition of biochemical's...[more]
Cancer Type	Oesophageal	Keywords
Project Type	Basic laboratory	Investigators	Gerald OSullivan
Project Code	CRI02OSU	Centre	Cork Cancer Research Centre

Project Title	The role of human RAD30 in the cellular response to chemotherapeutic agents...[more]
Cancer Type	Ovarian	Keywords	cisplatin, toxicity, DNA polyerase eta, mitomycin C, DNA replication
Project Type	Basic laboratory	Investigators	Michael Carty
Project Code	CR103CAR	Centre	Detartment of Biochemistry, NUI, Galway

Project Title	Regulation of T-lymphocyte cell susceptibility to apoptosis via the death inducing signaling complex (DISC) in prostate cancer...[more]
Cancer Type	Prostate	Keywords
Project Type	Basic Research	Investigators	Rosemary OConnor
Project Code		Centre	Mater Hospital

Project Title	Altering the anti-apoptopic phenotype of prostate cancer cells by RNA interface...[more]
Cancer Type	Prostate Cancer	Keywords
Project Type	Laboratory	Investigators	William Watson
Project Code	CRI03WAT	Centre	National University of Ireland, Dublin

Project Title	Proteomic analysis of the impact of an EGFR antagonist on the combined hormonal therapy and radiation therapy of high risk localized prostate cancer...[more]
Cancer Type	Prostate Cancer	Keywords	Prostate cancer, Proteomics, Radiation, Hormones, EGFR
Project Type	Cancer Related Biology	Investigators	John Armstrong
Project Code	CRI04ARM	Centre	St Luke's Hospital, Highfield Road, Rathgar, Dublin 6

Project Title	Development of new diagnostic, prognostic and therapeutic agents in prostate cancer...[more]
Cancer Type	Prostate Cancer	Keywords	Prostate Cancer, Tissue Bank, Methylation, Apoptosis,
Project Type	Cancer Progression and Metastasis	Investigators	Hollywood
Project Code	PCI03HOL	Centre	Clinical Oncology, St James Hospital, Trinity College Dublin, Department of Haematology, Institute of Molecular Medicine, St James Hospital, Trinity College Dublin, Department of Surgery, Mater Misericordiae University Hospital, Conway Institute, UCD

Project Title	Impact of an educational support group...[more]
Cancer Type	Prostate Cancer	Keywords	Prostate Cancer, informational support, patient education, Quality of Life
Project Type	Education and Communication	Investigators	Anita ODonovan
Project Code	PCI03ODO	Centre	Radiotherapy Dept., Saint Luke’s Hospital, Rathgar, Dublin 6.

Project Title	Novel approaches to generate improved methods for the detection of prostate cancer...[more]
Cancer Type	Prostate Cancer	Keywords	Antibodies, immunoassay, single chain variable fragment, prostate specific antigen (PSA)
Project Type	Technology and/or Marker Testing in a Clinical Setting	Investigators	Richard O'Kennedy
Project Code	PCI03OKE	Centre	School of Biotechnology, Dublin City University, Glasnevin, Dublin 9

Project Title	Predicting normal tissue toxicity in prostate cancer following 3D Conformal radiation therapy. A novel approach to the delineation of organs at risk and the use of individualised predictive indicators....[more]
Cancer Type	Prostate Cancer	Keywords	Prostate cancer, radiotherapy, toxicity, predictive factors
Project Type	Localized Therapies - Clinical Applications	Investigators	Pierre Thirion
Project Code	PCI03THI	Centre	Clinical Trials Unit, St Luke's Hospital, Rathgar

Project Title	Distress Management - The key to a comprehensive Psycho-Oncology service at Cork University Hospital Cancer Centre...[more]
Cancer Type	Psychology	Keywords	Distress depression mental health screening
Project Type	Patient Care and Survivorship Issues	Investigators	Eugene Cassidy
Project Code	PSY04CAS	Centre	Cancer Centre & Department of Psychiatry, Cork University Hospital

Project Title	A study of the metastatic potential of non-melanoma skin cancer in the immunosuppressed patient...[more]
Cancer Type	Skin	Keywords
Project Type	Basic Research	Investigators	Sharon McKenna
Project Code		Centre	RCSI

Project Title	Second generation inactivators of O6-alkylguanine-DNA alkyltransferase ...[more]
Cancer Type	Skin	Keywords
Project Type	Basic Research	Investigators	Brian McMurry
Project Code		Centre	TCD

Project Title	Analysis of RAD30 mutations in skin tumours...[more]
Cancer Type	Skin	Keywords	Skin cancer, UV light, Mutations, RAD30, Polymerase eta
Project Type	Laboratory	Investigators	Michael Carty
Project Code	CRI02CAR	Centre	National University of Ireland, Galway

Project Title	Genetics of protein tyrosine phosphatases (PTP's) in cancer...[more]
Cancer Type	Skin, Breast	Keywords
Project Type	Basic Research	Investigators	David Easty
Project Code		Centre	NUID

Project Title	Enhanced anticancer drug delivery via a combination of electrosensitisation and high frequency ultrasound...[more]
Cancer Type	Various	Keywords	electroporation, high frequency ultrasound, bleomycin
Project Type	Localized Therapies - Discovery and Development	Investigators	Gerald OSullivan
Project Code	CRI04OSU	Centre	Cork Cancer Research Centre, Mercy University Hospital and Biosciences Institute, University College Cork.

Page last updated: January 04 2010

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