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Our research projects

Our research projects

Project title Investigator(s) Cancer type(s) Centre Start date End date Lifetime amount
Glycosylation changes in cancer: a new class of biomarkers for breast and lung cancer
 		Professor Pauline Rudd  Breast & Lung  NUI, Dublin 01/04/2008 01/05/2011 €239,286
Children with cancer: Children, parents, and health professionals’ perspectives on children’s participation in shared decision-making.
 		Dr Imelda Coyne  Psycho-Oncology  Trinity & St James's 01/04/2008 01/12/2010 €92,009
Expressional and Functional Studies of Large ncRNAs in Neuroblastoma Pathogenesis.
 		Professor Raymond Stallings  Brain Tumours  RCSI & Beaumont 01/10/2008 01/09/2011 €239,482
HPV mRNA and p16 INK4a detection for improved diagnosis and management of cervical neoplasia in smokers.
 		Ms Christine White  Cervical  Trinity & Coombe Hospital 01/10/2009 30/09/2012 €119,990
Exploring the association between visceral adipose tissue and gastrointestinal malignancy: the role of insulin-like growth factor pathway
 		Dr Claire Donohoe  Gastrointestinal  Trinity & St James's 01/10/2009 30/09/2012 €118,810
FLT3 signaling in Acute Myeloid Leukaemia
 		Ms Joanna Stanicka  Leukaemia  NUI, Cork 01/10/2011 30/09/2014 €116,310
The interactions of Nox4 and Bcr-Abl in the survival of leukaemia cells
 		Mr William Landry  Leukaemia  NUI, Cork 01/10/2010 30/09/2013 €119,770
Targeting the mitochondrial mediated apoptosis pathway to promote cancer cell death
 		Professor Mark Lawler  Leukaemia  Trinity & St James's 01/10/2008 01/09/2011 €207,766
Tissue and serum microRNA signatures for predicting response to chemoradiotherapy of oesophageal adenocarcinoma
 		Dr Stephen Maher  Oesophageal  Trinity & St James's 01/10/2010 30/09/2013 €208,001
The role of the chemokine CCL28 (MEC) in oesophageal adenocarcinoma progression; interactions between the tumour and the immune system
 		Dr Sarah Picardo  Oesophageal  Trinity & St James's 01/10/2010 30/09/2013 €117,054
The Importance of Random Mitochondrial Mutations during Disease Progression in Barrett's Oesophagus
 		Dr Naoimh O'Farrell  Oesophageal  Trinity & St James's 01/10/2011 30/09/2014 €116,400
An investigation of the thromboxane and prostacyclin synthase pathways in non-small cell lung cancer
 		Dr Ken O'Byrne  Lung  Trinity & St James's 01/04/2008 01/05/2011 €224,086
The Identification of Biomarkers that Predict Sensitivity/Resistance to PI3K Inhibitors.
 		Ms Susan Heavey  Lung  Trinity & St James's 01/10/2011 30/09/2014 €119,273
Anti-angiogenic Gene Therapy for Breast Cancer
 		Dr Mark Tangney  Breast  NUI, Cork 01/04/2008 01/05/2011 €195,332
Understand Cdc7/Dbf4 regulation by microRNAs and its impact in cancer and differentiation
 		Dr Laura Barkley  Breast  NUI, Galway 01/10/2008 01/09/2011 €224,915
Investigation of the potential of human Mesenchymal Stem Cells (hMSC) as vectors for therapeutic gene delivery to breast tumor tissue
 		Dr Roisin Dwyer  Breast  NUI, Galway 01/04/2008 01/05/2011 €145,019
Role of xbp1 in breast cancer development and resistance to therapy
 		Ms Patricia Cleary  Breast  NUI, Galway 01/10/2011 30/09/2014 €120,000
The Role of HER Family Gene Mutations and Other Abnormalities in HER2-amplified Breast Cancer Resistance to HER2-Targeted Therapies.
 		Ms Naomi Elster  Breast  RCSI & Beaumont 01/10/2011 30/09/2014 €120,000
An analysis of how Q-tRNA influences breast cancer growth and metastasis
 		Ms Claire Fergus  Breast  Trinity 01/10/2011 30/09/2014 €116,950
The role of ADAMs in mediating resistance to HER-targeted therapies
 		Dr Patricia McGowan  Breast  UCD & St Vincent's 01/10/2011 30/09/2014 €217,936
To investigate how RACK1 facilitates the activity, substrate specificity and cellular location of PP2A in mammary epithelial cells.
 		Ms Maeve Kiely  Breast  UL 01/10/2011 30/09/2014 €120,000
Identification and characterisation of guanine nucleotide exchange factors (GEFs) which activate Rab25 during invasive ovarian cancer cell migration
 		Dr Conor Horgan  Ovarian  NUI, Cork 01/10/2011 30/09/2014 €198,474
microRNA Regulation of the Spindle Assembly Checkpoint (SAC): Implications for Cell Cycle Dysregulation in Ovarian Cancer and Taxol Responsiveness
 		Dr Fiona Furlong  Ovarian  NUI, Dublin 01/10/2008 01/09/2011 €224,826
The inverse resistance relationship between platinum and taxane chemotherapy in ovarian cancer.
 		Dr Britta Stordal  Ovarian  Trinity & St James's 15/11/2010 14/10/2013 €197,173
Regulation and Function of Toll-like Receptors in Ovarian Cancer: A Synergistic Model.
 		Professor John O'Leary  Ovarian  Trinity & St James's 01/10/2008 01/09/2011 €150,000
Hsa-miR-141 and hsa-miR-223 are central to Ovarian Serous Carcinoma Pathogenesis through Regulation of JAG1 and SMARCD1 proteins.
 		Dr Richard Flavin  Ovarian  Trinity & St James's 01/04/2008 01/05/2011 €168,697
Meaningful methods of identifying psychological distress in patients with advanced cancer
 		Dr Pamela Gallagher  All Cancers  DCU 01/10/2008 01/09/2010 €120,143
To determine how RACK1 regulates cell migration during tissue morphogenesis and tumorigenesis using 3D culture model systems.
 		Dr Patrick Kiely  All Cancers  NUI, Cork 01/10/2009 30/09/2012 €240,188
Combined biotherapeutics for the treatment of metastatic cancer
 		Dr Michelle Cronin  All Cancers  NUI, Cork 01/10/2011 30/09/2014 €190,824
Redox regulation of apoptosis modulating survival pathways in re-current tumours
 		Professor Tom Cotter  All Cancers  NUI, Cork 01/04/2008 01/05/2011 €236,528
Investigation into the inhibition of angiogenesis by serpins.
 		Dr Margaret Worrall  All Cancers  NUI, Dublin 01/10/2008 30/09/2011 €138,594
Targeting the Hsp70-IRE1 complex for cancer therapy
 		Ms Lisa Vincenz  All Cancers  NUI, Galway 01/10/2010 30/09/2013 €120,000
Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis
 		Dr Eva Szegezdi  All Cancers  NUI, Galway 01/10/2009 30/09/2012 €195,592
Mechanisms underlying a psychological intervention for prolonged cancer-related fatigue: a role for symptom perceptions?
 		Ms Maria Pertl  All Cancers  Trinity & St James's 01/10/2009 30/09/2012 €45,000
Role of the Bcl-2 family protein, Noxa, in sensitivity to platinum-based chemotherapeutics
 		Professor Seamus Martin  All Cancers  Trinity & St James's 01/10/2008 01/09/2011 €223,166
Specific Targeting of Cancer Stemness: Potential Cancer Therapy?
 		Professor John O'Leary  All Cancers  Trinity & St James's 01/04/2008 01/05/2011 €150,000
Serological detection and biological validation of antibody-based biomarkers specific to colorectal cancer
 		Dr Gregor Kijanka  Colorectal  DCU 01/10/2010 30/09/2013 €219,985
Investigating factors associated with compliance in the national population-based colorectal cancer screening programme, with particular emphasis on men.
 		Mr Nicholas Clarke  Colorectal  NUI, Cork 01/10/2011 30/09/2014 €116,095
Metformin & Colorectal Cancer Outcomes
 		Ms Susan Spillane  Colorectal  Trinity & St James's 01/10/2010 30/09/2013 €85,554
Examination of the role of thromboxane synthase signalling and its link to tumour angiogenesis in colorectal cancer
 		Dr Mary Clare Cathcart  Colorectal  Trinity & St James's 01/10/2011 30/09/2014 €196,694
Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer
 		Prof William Watson  Prostate  NUI, Dublin 01/10/2011 30/09/2014 €750,000
Cardiac Glycosides and Prostate Cancer Incidence, Outcomes
Ms Eva Flahavan  Prostate  Trinity & St James's 01/10/2010 30/09/2013 €86,554
DNA methylation in prostate cancer: further evaluation of GSTP1, SFRP2 and IGFBP3 as prognostic biomarkers and an unmasking of epigenetically controlled miRNAs.
 		Dr Antoinette Perry  Prostate  Trinity & St James's 01/10/2009 30/09/2012 €212,627

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