Our research projects

Our research projects

Project title Investigator(s) Cancer type(s) Research Institution Start date End date Lifetime amount
Targeting multidrug resistance in glioblastoma multiforme
Dr Amanda Tivnan  Brain Tumours  RCSI & Beamount 21/10/2013 20/10/2016 212789
FLT3 signaling in Acute Myeloid Leukaemia
Ms Joanna Stanicka  Leukaemia  UCC, Cork 01/10/2011 30/09/2014 €116,310
The interactions of Nox4 and Bcr-Abl in the survival of leukaemia cells
Mr William Landry  Leukaemia  UCC, Cork 01/10/2010 30/09/2013 119770
Tissue and serum microRNA signatures for predicting response to chemoradiotherapy of oesophageal adenocarcinoma
Dr Stephen Maher  Oesophageal  TCD & St James's 01/10/2010 31/07/2012 208001
Elucidating the crosstalk between oesophageal tumours and the immune response in patients receiving chemoradiation treatment: identification of novel prognostic markers and therapeutic strategies.
Dr Maria Morrisey  Oesophageal  TCD & St James's 31/12/2013 30/12/2016
Exploring the link between obesity and oesophageal adenocarcinoma: the role of STAT3 inhibition
Dr Katie O'Sullivan  Oesophageal  TCD & St James's 02/10/2012 30/09/2016 140000
Investigation of the role of GOLPH2 in oesophageal cancer progression and its potential use as a serum biomarker
Dr Anne-Marie Byrne  Oesophageal  TCD & St James's 01/10/2012 30/09/2015 203199
Oesophageal cancer metastasis: investigation of the scaffolding protein RACK1 as a key player and therapeutic target
Ms Deirdre Duff  Oesophageal  TCD & St James's 01/10/2012 30/09/2016 139800
The importance of random mitochondrial mutations during disease progression in Barrett's Oesophagus
Dr Naoimh O'Farrell  Oesophageal  Trinity & St James's 01/10/2011 30/09/2014 €116,400
The role of the chemokine CCL28 (MEC) in oesophageal adenocarcinoma progression; interactions between the tumour and the immune system
Dr Sarah Picardo  Oesophageal  Trinity & St James's 01/10/2010 30/09/2013 €117,054
Investigation of the involvement of microRNAs in cell death susceptibility in Oesophageal Cancer
Dr Michelle Nyhan  Oesophageal  UCC 01/10/2012 30/09/2015 225000
The Identification of Biomarkers that Predict Sensitivity/Resistance to PI3K Inhibitors
Ms Susan Heavey  Lung  TCD & St James's 01/10/2011 30/09/2014 119273
Role of xbp1 in breast cancer development and resistance to therapy
Ms Patricia Cleary  Breast  NUIG, Galway 01/10/2011 30/09/2014 €120,000
The role of HER family gene mutations and other abnormalities in HER2-amplified breast cancer resistance to HER2-targeted therapies
Ms Naomi Elster  Breast  RCSI & Beaumont 01/10/2011 30/09/2014 €120,000
An analysis of how Q-tRNA influences breast cancer growth and metastasis
Ms Claire Fergus  Breast  Trinity 01/10/2011 30/09/2014 €116,950
IGF-1-regulated Mitochondrial Protein PNC1 as a marker of breast cancer invasiveness
Mr Michael Coleman  Breast  UCC 01/10/2012 30/09/2016 139540
The role of ADAMs in mediating resistance to HER-targeted therapies
Dr Patricia McGowan  Breast  UCD 01/12/2011 30/11/2014 €217,936
The role of the anorectic neuropeptide CART in breast cancer
Mr Brian Mooney  Breast  UCD 01/09/2013 31/08/2017 139500
Irish Cancer Society BREAST-PREDICT Collaborative Cancer Research Centre
Professor William Gallagher  Breast  UCD 01/09/2013 31/12/2014
To investigate how RACK1 facilitates the activity, substrate specificity and cellular location of PP2A in mammary epithelial cells
Ms Maeve Kiely  Breast  UL 01/10/2011 30/09/2014 €120,000
The inverse resistance relationship between platinum and taxane chemotherapy in ovarian cancer.
Dr Britta Stordal  Ovarian  TCD 15/11/2010 30/11/2013 €197,173
Identification and characterisation of guanine nucleotide exchange factors (GEFs) which activate Rab25 during invasive ovarian cancer cell migration
Dr Conor Horgan  Ovarian  UCC 01/11/2011 30/10/2014 204769
Social and spatial isolation as a determinant of cancer treatment and survival in Ireland
Dr Harry Comber  All Cancers  NCRI 05/12/2012 04/12/2013 134690
Targeting the Hsp70-IRE1 complex for cancer therapy
Ms Lisa Vincenz  All Cancers  NUIG, Galway 01/10/2010 31/05/2012 €120,000
Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis
Dr Eva Szegezdi  All Cancers  NUIG, Galway 01/12/2009 30/06/2013 €195,592
Combined biotherapeutics for the treatment of metastatic cancer
Dr Michelle Cronin  All Cancers  UCC, Cork 01/10/2011 30/09/2014 €190,824
Serological detection and biological validation of antibody-based biomarkers specific to colorectal cancer
Dr Gregor Kijanka  Colorectal  Dublin City University 15/09/2010 16/09/2013 219985
Molecular regulation of the tumor microenvironment in colon cancer metastasis
Dr Aideen Ryan  Colorectal  NUIG 01/01/2013 31/12/2015 224789
Metformin & Colorectal Cancer Outcomes
Ms Susan Spillane  Colorectal  TCD 01/10/2010 30/09/2013 €85,554
Examination of the role of thromboxane synthase signalling and its link to tumour angiogenesis in colorectal cancer
Dr Mary Clare Cathcart  Colorectal  Trinity & St James's 01/10/2011 30/09/2014 €196,694
Investigating factors associated with compliance in the national population-based colorectal cancer screening programme, with particular emphasis on men
Mr Nicholas Clarke  Colorectal  UCC 01/09/2012 30/08/2015 €116,095
Development of Novel Isoquinolone Drugs for the Treatment of Colorectal Cancer
Ms Clare Butler  Colorectal  UCD 01/10/2013 30/09/2017
Epigenetic regulation of the angiogenic switch and response to anti-angiogenic therapy in metastatic colorectal cancer
Dr Sudipto Das  Colorectal  UCD 01/10/2013 01/09/2016 235000
Targeting Protein Kinase C in Colorectal Cancer
Ms Catriona Dowling  Colorectal  UL 01/10/2012 30/09/2016 139100
Therapeutic microRNA control of Prostate Cancer growth
Dr Laura Barkley-Elliman  Prostate  NUIG 01/07/2011 31/12/2013 125070
Centrosome amplification and radiosensitization of prostate cancer cells
Professor Ciaran Morrison  Prostate  NUIG 01/10/2011 30/09/2014
Ultrafast dynamic contrast enhanced MRI using compressed sensing for improved prostate cancer diagnosis and staging
Mr Silvin Knight  Prostate  TCD & St James's 01/09/2013 31/08/2017 138700
DNA methylation in prostate cancer: further evaluation of GSTP1, SFRP2 and IGFBP3 as prognostic biomarkers and an unmasking of epigenetically controlled miRNAs
Dr Antoinette Perry  Prostate  TCD & St James's 01/10/2009 30/09/2012 240188
Prognosis potential of miRNAs in high-risk radiotherapy prostate cancer patients
Dr Laure Marignol  Prostate  TCD & St James's 01/12/2012 30/11/2015 297372
Cardiac Glycosides and Prostate Cancer Incidence, Outcomes
Ms Eva Flahavan  Prostate  Trinity & St James's 11/10/2010 10/10/2013
The use of non-viral vectors to effectively silence genes in primary and metastatic prostate cancer models
Mr James Evans  Prostate  UCC 01/10/2012 30/09/2016 136980
Bacterial-mediated therapy of prostatic tumours
Dr Mark Tangney  Prostate  UCC 01/12/2012 30/11/2015
Pre-clinical development of stealth cyclodextrin siRNA nano-delivery systems for prostate cancer treatment
Professor Caitriona O'Driscoll  Prostate  UCC 01/10/2011 30/09/2014 282013
Thromboxane (TX)A2 -mediated PRK1 signalling in Prostate Cancer: Does the TXA2 Receptor Serve as a Chemotherapeutic Target?
Professor Therese Kinsella  Prostate  UCD 01/12/2012 30/11/2015 296041
Building a pipeline for novel therapies in castrate-resistant disease: the SRF paradigm
Dr Maria Prencipe  Prostate  UCD 01/12/2012 30/11/2015
Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer
Prof William Watson  Prostate  UCD, Dublin 01/10/2011 30/09/2014 €750,000